To create the knowledge and tools to design and build novel biomolecular components, pathways, and networks to rewire and reprogram organisms to supply humanity's needs.
Enzymit’s technology allows for an unprecedented search of sequence space which is both expansive and focused. Protein sequence space for even small proteins is intractable. There are over 10 possible sequence changes for any given protein. Experimental screening can only test up to
10 -10 enzyme variants in a single experiment. These experiments are extremely laborious, time-consuming, and not generalizable.
We Are Building a
To improve existing enzyme functionality, at a fraction of the cost and time of alternative approaches.
To invent new enzymes to address unmet market needs.
Enzyme’s 3D structures define their function (their ability to work on the desired chemical) Each chemical requires the correct shape (conformation). To build new enzymes we need more structures. There are only a limited number of known enzyme structures (gathered from experiments). Compared to the vast protein sequence data
we have obtained through various genome projects.
Protein sequence space is for even small proteins is intractable. There are over 10 possible sequence changes for any given protein
Data gathered is fed into deep learning algorithms for continuous optimization of our enzyme design pipeline
design algorithms for new
chemistry enzyme design
Novel, proprietary experimental tools for high throughput testing of enzyme variants